Imagine a world where every capsule or tablet has a perfect blend of active ingredients. In the pharmaceutical field, that's where the bin blender comes in, mixing fine powders perfectly. However, choosing the wrong one could spell disaster. No worries! In this article, we'll walk you through the key things to look for before purchasing a powder mixer, to ensure that your pharmaceutical business gets the perfect blend - both figuratively and literally.
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Question 1: What Type of Materials Will You be Blending?
When selecting a bin blender for your pharmaceutical application, the crucial first step is to determine the specific type of material you want to blend.
Powders are the most common pharmaceutical blending category and include a wide variety of ingredients such as active pharmaceutical ingredients (APIs), excipients (fillers, binders, disintegrants) and lubricants. However, there is much more diversity within powders:
- Fine powders - These powders have a particle size of less than 100 microns and require gentle mixing in a blender to prevent excessive shearing and potential degradation.
- Coarse powders - These powders have larger particles and can withstand more vigorous mixing.
In addition, pharmaceutical formulations often require pre-processed particles for controlled release or improved flowability. Therefore, it is important to consider the size, density and shape of the particles when selecting a blender.
Apart from the above two common materials, there are some more challenging ones, such as:
- Sticky powders - These powders tend to agglomerate and require mixers with specific blade designs to break up the agglomerates.
- Moisture sensitive materials - hygroscopic materials (such as some APIs) tend to absorb moisture. Consider using a blender with vacuum capabilities to minimize moisture exposure during the blending process.
- Shear sensitive materials - Some APIs can lose their effectiveness or change their properties under high shear. For these materials, a mixer with a gentler mixing mechanism or adjustable settings is required.
Question 2: What is Your Desired Blend Uniformity?
When choosing a bin blender, material blend uniformity might be another big factor you need to consider. Inconsistent mixing of ingredients can cause some problems with your finished product. If certain doses of the API are low in concentration, they may not be enough to treat the intended condition. In contrast, high concentrations of APIs may cause unwanted side effects.
The features of the blender largely determine the level of material blending uniformity.
The longer the mixing time, the more uniform the mix will be. Therefore, you need to consider the mixer's operating cycle and how it matches your desired batch uniformity.
Also, some blenders use a tumbling action, while others use a specific blade configuration for optimal particle distribution. When selecting a blender, choose the mixing method that is right for your batch and desired uniformity.
Mixing larger batches can be more challenging to achieve uniform distribution. At this point, you're better off choosing a blender that has the capacity to easily handle typical batch sizes without compromising uniformity.
Question 3: How Much Do You Plan to Produce Daily, and in How Many Batches?
Think of your daily production as the big picture - the total amount of final product you need to produce each day. This helps determine the overall amount of work the bin blender needs to handle.
Batch size, on the other hand, refers to how much material you want to mix at one time. Factors such as the type of medication you are making and other equipment limitations can affect this decision.
Now, by knowing your daily production and typical batch sizes, you can determine the ideal number of batches you need to run each day. A simple calculation will help you do this.
- Daily Production Volume / Batch Size = Number of Batches
This will tell you how many runs the blender needs to run to reach your production goals.
Now that you know the ideal number of batches, let's find the perfect bin blender! The capacity and efficiency of your blender are key considerations. Not only should you make sure the blender is right for your typical batch size. This is because overloading can negatively impact mixing and uniformity.
You also want to look for machine features that minimize downtime between batches. This may include fast loading/unloading functions and easy-to-clean designs for faster turnaround.
Question 4: What Materials are Used in the Blender's Construction?
In general, stainless steel is the material of choice for pharmaceutical blenders. It offers several advantages'
- Corrosion Resistant - Stainless steel is very resistant to corrosion from pharmaceutical ingredients and cleaning agents, which prevents contamination of the blender itself.
- Easy to clean - Stainless steel produces blenders with smooth, crevice-free internal surfaces that are easy to clean, minimizing product residue and maintaining sanitation.
- Durable - Stainless steel maintains excellent durability and longevity even under harsh operating conditions.
Just as importantly, make sure that the mixer's gaskets and seals are made of materials compatible with the medication components and cleaning solvents. This will prevent them from degrading or leaching chemicals into the mixture.
In any case, it is important to remember that the right machine construction materials are an investment in the quality and safety of your medicines. Don't compromise on this critical aspect when choosing a bin blender.
Questions 5: What is the Motor Power of the Bin Blender?
The motor power of the bin blender is critical to ensure efficient mixing. Usually you can determine the proper motor power based on your batch size.
- Small Batch (1-5 kg): For lighter, small batch powders, a bin blender with a motor in the 0.75-1.5 kW range may be enough.
- Medium Batches (5-10 kg): For medium batches of materials, you can go for a blender with a motor power between 1.5 kW and 2.2 kW. This kind of machine can also be used for denser powders or mixtures of particle sizes.
- Large quantities (10 kg and above): Large quantities or denser materials may require a motor of 2.2 kW or more to ensure proper blending.
These are just general examples, your specific power requirements for a bin mixer depend on your unique needs. It is always best to consult the bin blender manufacturer to discuss your application. They can recommend a blender with the proper motor power and mixing capacity to achieve the best performance for your needs.
The Bottom Line
Choosing the right bin blender for your pharmaceutical operation doesn't have to be a complex process. This guide provides you with 5 key questions to ask. With these insights, you will have no trouble selecting the perfect blender that can help you boost your pharmaceutical business.
When manufacturing products for the food, nutrition, bakery and chemical sectors, it is likely that you will need to blend a mix of powder ingredients. In the majority of applications, blending is the most important process to increase the value of the product. If you are handling a wide range of ingredients, some of these may pose an allergen risk and whilst several manufacturers are willing to make significant investments by installing the highest speed mixers and packing lines, it does not necessarily mean it will deliver a strong return on investment and long-term efficient solution.
The most important thing to consider is whether to batch or continuously manufacture. If you need to swap recipes on a regular basis or produce the same product day in day out, then your application will be better suited to certain blender types.
Do you need to blend a variety of products?
If you only have a requirement to manufacture one recipe in a large volume with no regular changes needed then you should continuously process with a fixed mixer coupled to the upstream and downstream processes. However, with more manufacturers finding that consumers are requesting recipe variety, changes need to be made quickly and efficiently. If you are finding that you need to change recipes and use varied ingredients regularly then batch processing would be the best way to manufacture.
Even if you are an experienced powder processing professional, technology moves on and the choice of mixers continues to expand. To help you select the right industrial mixer for your application, we have listed 5 key considerations for manufacturer's who are looking to select an industrial powder mixer for blending as part of a batch processing programme.
See how the IBC Blender eliminates the time consuming cleaning associated with traditional static mixers.
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The Characteristics of the Powder
Are you handling free-flowing powders with similar particle sizes? If this is the case and you know that your recipe will mix easily then a gentle blending programme will be best suited using either a tumble-blender or ribbon blender.
If you are handling sticky, cohesive powders and need them to mix homogeneously, you will need to work the mixture to force the particles to fold together. A blender that offers high shear capability in the form of intensifiers would be required. It is vital that the right amount of shear is applied to blend the particles. If this process is mismanaged then particle degradation and heat may build-up in the mixture.
The Size of the Batch Being Produced
Although large blenders have the ability to accommodate a full order size, it is likely that the load time and cleaning times will increase. Considerations need to be given to the time it takes to fill the blender by ripping and tipping 25kg sacks and then to discharge the mixed product to a packing line - you also have cleaning! Whilst the mixer is being loaded, emptied and cleaned it is not in use, leading to large amount of downtime.
If your customers require the same order sizes each time then a fixed mixer may work well until variable batch sizes are required. When using a tumble blender, you will be given the ability to blend a range of batch sizes in one blender as the mixing is done in the Intermediate Bulk Container (IBC). This gives you the option to choose the size of the container needed and reduce the amount of downtime.
Understand the True Mixing Time
Try not to be misled by the suggestion of a 4 minute blend time. The full end to end process time that includes all stages of blending from filling through to packing and cleaning needs to be taken into account. The time it takes to get your mixer back into operation and ready for the next batch could actually mean 2 hours to load and then 3 hours for packing.
Whilst IBC Blending might take a little longer to complete a full blend cycle, the formulation can be completed off-line. As the IBC is also removed from the blender and packed separately the mixer can be re loaded and set back into action. By running the filling, mixing and packing process steps in parallel means you save a significant amount of time, with the added benefit that the blender will not need to be cleaned.
How easy is it to clean your Industrial Mixer?
Some fixed blenders with multiple moving parts can lead to product loss. All fixed mixers will inevitably have some product left inside either the base of the mixer bowl or sticking to the sidewalls, paddles or bearings. Not only does this lead to large amounts of waste long term but also potential contamination across batches.
As mentioned above the true time of blending in an IBC will also include cleaning. If you need to take the fixed mixer apart, remove the contact parts and then perform a full wet wash with drying times factored in then the mixer will be out of action for a significant amount of time. Further considerations should be paid to:
The fact remains that cleaning down and drying a fixed mixer takes a significant amount of time, it is labour intensive and wastes materials however with in-bin blending, the recipe is blended in the container, which can then be cleaned 'off-line'. Once cleaned, IBCs can be returned to the manufacturing process to maintain an efficient process flow.
Risk of Cross-Contamination
As the number of ingredients used in recipes increases, so does the potential for allergens to be present. It is a challenge for manufacturers to perform recipe changeovers and clean-downs efficiently and effectively. As fixed mixers and in-line conveying systems are coupled, it can take a long time to clean parts and equipment between batches and then validate that the production line is actually clean.
If you are mixing various recipes on the same blender then there is a high risk of cross-contamination. To reduce any risks, some companies dedicate a single blender to recipes containing allergens. Whilst this can be an option if only one additional fixed mixer is needed, it is not good practice or economical if you need half a dozen!
IBC blending provides manufacturers with a simple, safe solution. The IBCs are used for one recipe and then cleaned (offline) before being reintroduced to the process. As there are no blender parts in contact with the product the same blender can be used again on a different batch.
Containers with butterfly valves can still experience mix segregation issues due to core flow. Cone Valve IBCs offer the best way to stop segregation as the product flows under mass-flow discharge meaning that all particles move down through the bin in unison.
Some things to remember when blending powders:
It is possible to reduce the amount of time wasted in cleaning.
Better efficiency at the blending process stage could increase output resulting in a higher number of batches being produced in a single shift.
A tumble blender will reduce the number of operators required for cleaning.
Using Matcon IBCs with integral Cone Valve technology means that no product is left in the container.
It is possible to manufacture a wide range of recipes and batch sizes efficiently.
It is important that you are not selecting what appears to be the cheapest option in the short term. Remember not to focus on just the blend time and be wowed by fast mixers that will actually lead to large amounts of downtime and a poor ROI. Make sure you invest in a flexible manufacturing system which gives you a competitive advantage.
Final Thoughts
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