Buy Smart PS™ Phosphatidylserine Softgels

Smart PS™ Phosphatidylserine Softgels are receiving rave reviews for their significant cognitive benefits, as numerous studies highlighted their efficacy in enhancing memory, focus, and overall brain health, making it a highly sought-after supplement.

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Differences Between Smart PS™ and Smart PS™ Green

Smart PS is a phosphatide complex that contains a blend of Phosphatidylserine, Phosphatidylcholine, and Phosphatidylethanolamine. Smart PS Green contains Phosphatidylserine only and is a soy-free variation of Smart PS derived from sunflower.

What is Phosphatidylserine?

Phosphatidylserine (PS) is a phospholipid that is a major component of cell membranes, making it a highly valuable nutrient for supporting cognitive function. Without sufficient levels of phosphatidylserine, brain cells may not transmit nerve impulses properly.

Phosphatidylserine is highly unstable and therefore prone to degradation. To overcome the issue of phosphatidylserine stability, enter Smart PS™ — an exclusive fluid dispersion of phosphatidylserine material, provided as finished dosage softgels, which has enviable stability. Shelf-life studies on Smart PS™ found that even after 24 months, the material showed absolutely no degradation. Smart PS™ Softgel Capsules are soy-derived. For those that are sensitive or allergic to Soy, we now also have a soy-free formulation that is derived from sunflower, called Smart PS Green. Smart PS Green still boasts the same great stability and bioavailability that is characteristic of soy-derived Smart PS, allowing you to reap the same benefits, without the soy!

Smart PS™ enhanced-stability phosphatidylserine softgels overcome the problem of phosphatidylserine degradation for maximum brain benefits.* Smart PS™ finished dosage softgels feature an exclusive fluid dispersion phosphatidylserine material that has significantly enhanced stability for maximum brain benefits.*

Phosphatidylserine Benefits and Uses

• May help promote cognitive function*
• May help support feelings of well-being*
• May help support energy*
• May help promote healthy sleep habits*

Phosphatidylserine vs Phosphatidylcholine

As phospholipids, both Phosphatidylserine (PS) and Phosphatidylcholine (PC) are major components of cell membranes. However, unlike phosphatidylserine, phosphatidylcholine has very limited value in improving mental function. Why? Weak bioavailability. As a nutritional supplement, Phosphatidylcholine is hoarded by the liver. As a result, hardly any of it actually makes it to the brain. Phosphatidylserine, on the other hand, is a modified form of phosphatidylcholine that does get to the brain, making it a highly valuable nutrient for enhancing cognitive function. Phosphatidylserine benefits may promote cognitive function, support energy, promote feelings of well-being, and healthy sleep habits. However, phosphatidylserine sleep benefits have only been found in limited clinical trials.

What is Phosphatidylcholine?

Phosphatidylcholine is a phospholipid with two fatty acids bound to a glycerol backbone and is a major component of cell membranes. It is found in the highest concentrations within the liver and the brain. Phosphatidylcholine benefits are derived from the fact that it is a choline source and that a phosphatidylcholine supplement may enhance the production of acetylcholine in neurons, which ultimately promotes cognitive function. Yet, Phosphatidylcholine benefits are hard to achieve due to its poor bioavailability. Phosphatidylcholine benefits were noted in a trial aiming to reduce localized fat relative to baseline data. However, this was only achieved through injection, and results were inconsistent. Membrane-mediated cell signaling and phosphatidylcholine transfer protein activation is believed to be the bulk of phosphatidylcholine function.

Fortunately, Phosphatidylcholine and Phosphatidylserine benefits can be easily reaped with Smart PS™ softgels. Phosphatidylserine is a modified form of Phosphatidylcholine that actually reaches the brain. Pharmacokinetic studies show that supplemental Phosphatidylserine easily crosses the blood-brain barrier, making it a highly valuable nutrient for promoting cognitive function.*

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Research on Phosphatidylserine (PS)

Phosphatidylserine Benefits in Animals and Humans

Research in Animals and in Humans has shown that Phosphatidylserine (PS) may:

• Support mood
• Support cognitive function
• Enhance athletic performance and recovery

Phosphatidylserine Dosage

As a dietary supplement, take one 100mg Smart PS™ or Smart PS™ Green softgel daily.

Phosphatidylserine Reviews

To gain more insight, see the Phosphatidylserine supplement reviews and experiences below.

Where to Buy Phosphatidylserine Supplement

Nootropics Depot offers 60ct and 120ct jars of high-quality Phosphatidylserine. Nootropics Depot’s Phosphatidylserine has been lab-tested and verified for both product purity and identity.

Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*Smart PS Contains Soy Allergens. Smart PS Green contains Phosphatidylserine only and is a soy-free variation of Smart PS derived from sunflower.

Phosphatidylserine (PS) – Frequently Asked Questions

What is PS good for? Who might benefit from supplementation?

• PS improves memory and cognition as we age. Research has shown that both those with normal age-related cognitive decline and those with Alzheimer's disease benefit from supplementation with PS.
• PS supports focus and attention in children. In one study, children with ADHD who received a daily PS supplement saw improvements in their short-term memory and their ADHD symptoms.
• PS improves the brain's ability to handle stress and helps to create feelings of greater calm and relaxation in the face of stressors, especially in those who are chronically stressed.
• PS improves feelings of depression in elderly people. In a study where depressed elderly people took a supplement containing PS, DHA, and EPA (omega-3s), their symptoms of depression improved significantly, and those who saw the greatest benefits also saw their elevated cortisol levels return to normal and their circadian rhythms (sleep-wake cycle) normalized.
• PS supports exercise performance and recovery in a wide array of athletic endeavors. In golf, PS increased the number of good ball flights during tee-off and moderately improved perceived stress levels. PS supplementation also improves perceived well-being and muscle soreness after intense muscle training. And it has been shown to improve muscle soreness and oxidative stress in cyclists and runners.

How to supplement?

PS supplements are most commonly derived from soy lecithin, but there are also versions derived from sunflower lecithin for those looking for a soy-free option. Doses range from 100 mg/day for children and for healthy adults for maintenance, 300mg/day (usually divided into 3 doses) for memory and cognition issues, and up to 600 mg/day for mood issues and short-term supplementation related to athletics. PS also appears to have a synergistic effect with the omega-3 fatty acid DHA, so it is a good idea to also supplement with DHA to get the most brain benefits. There are also PS products combined with DHA to make this easier.

How long until you see results?

In general, it may take up to 3 months to see results from PS supplementation. Remember it is helping to build healthier brain cells, and that can take time. PS for exercise might be an exception to this rule, since some studies have shown benefits in as few as 10 days of PS supplementation.

Cautions

PS is generally well-tolerated, with very few side effects reported. However, if you have a serious health condition or are taking prescription medication, it is always a good idea to check with your doctor or pharmacist before starting a new supplement. And, the safety of PS for pregnant women and those who are breastfeeding has not been established, so it is probably best to avoid it in these circumstances.

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References

1. n.a. (1999). Phosphatidylserine Monograph. Alternative Medicine Review, 4(2), 115-117. Retrieved from https://altmedrev.com/wp-content/uploads/2019/02/v4-2-115.pdf
2. Klinkhammer, P., Szelies, B., Heiss, W.-D. (1990). Effects of phosphatidylserine on cerebral glucose metabolism in Alzheimer’s disease. Dement Geriatr Cogn Disord, 1(4), 197-201. https://doi.org/10.1159/000107142
3. Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., & Miyamori, T. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of clinical biochemistry and nutrition, 47(3), 246–255. https://doi.org/10.3164/jcbn.10-62
4. Zhang, Y. Y., Yang, L. Q., & Guo, L. M. (2015). Effect of phosphatidylserine on memory in patients and rats with Alzheimer's disease. Genetics and molecular research: GMR, 14(3), 9325–9333. https://doi.org/10.4238/2015.August.10.13
5. Crook, T. H., Tinklenberg, J., Yesavage, J., Petrie, W., Nunzi, M. G., & Massari, D. C. (1991). Effects of phosphatidylserine in age-associated memory impairment. Neurology, 41(5), 644–649. https://doi.org/10.1212/wnl.41.5.644
6. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., Tatsumi, Y., Purpura, M., & Jäger, R. (2014). The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. Journal of human nutrition and dietetics: the official journal of the British Dietetic Association, 27 Suppl 2, 284–291. https://doi.org/10.1111/jhn.12090
7. Baumeister, J., Barthel, T., Geiss, K. R., & Weiss, M. (2008). Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutritional neuroscience, 11(3), 103–110. https://doi.org/10.1179/147683008X301478
8. Hellmammer, J., Vogt, D., Franz, N., Freitas, U., Rutenbergy, D. (2014). A soy-based phosphatidylserine/phosphatidic acid complex (PAS) normalized the stress reactivity of the hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health, 13(121). https://doi.org/10.1186/1476-511X-13-121
9. Benton, D., Donohoe, R. T., Sillance, B., & Nabb, S. (2001). The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutritional neuroscience, 4(3), 169–178. https://doi.org/10.1080/1028415x.2001.11747360
10. Komori T. (2015). The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Mental illness, 7(1), 5647. https://doi.org/10.4081/mi.2015.5647
11. Jäger, R., Purpura, M., Geiss, K. R., Weißen, M., Baumeister, J., Amatulli, F., Schröder, L., & Herwegen, H. (2007). The effect of phosphatidylserine on golf performance. Journal of the International Society of Sports Nutrition, 4, 23. https://doi.org/10.1186/1550-2783-4-23
12. Fahey, T., Pearl, M.S. (1998). The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biology of Sport, 15(3), 135-144.
13. Jäger, R., Pupura, M., Kingsley, M. (2007). Phospholipids and sports performance. J Int Soc Sports Nutr, 4, 5. doi: 10.1186/1550-2783-4-5
14. Monteleone, P., Beinat, L., Tanzillo, C., Maj, M., & Kemali, D. (1990). Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology, 52(3), 243–248. https://doi.org/10.1159/000125593
15. Kidd P. M. (1999). A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Alternative medicine review: a journal of clinical therapeutic, 4(3), 144–161. Retrieved from https://altmedrev.com/wp-content/uploads/2019/02/v4-3-144.pdf
16. Fahey, T., Pearl, M.S. (1998). The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biology of Sport, 15(3), 135-144.
17. Kim, H-Y., Huang, B.X., Spector, A.A. (2014). Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res, 0, 1-18. doi: 10.1016/j.plipres.2014.06.002
18. Starks, M.A., Starks, S.L., Kingsley, M., Purpura, M., Jäger, R. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr, 5(11). https://doi.org/10.1186/1550-2783-5-11